The Binding of Isaac (more specifically, the Repentance DLC) is boring, the items are terribly designed and terribly balanced (on top of the item list being incredibly bloated), and the game relies far too much on luck for many deaths to truly feel as though they were preventable.
Unless you get a good item on your first floor, each room is a slog to get through, especially on the Cellar floor. Any character which uses tears (a majority of them) takes forever to kill most enemies, even in the early floors, which makes the game downright boring to play. Get ready to hold your R key down every time your starting item is subpar.
TBOI's item pool is filled with minor effects and stat boosts that range from negligible to downright harmful to a build. This, combined with your incredibly minimal control over the items you find, makes for a frustrating experience past the first 20 or so hours.
Compare it to Risk of Rain 2, one of my personal favorites in the roguelike/roguelite genre, for example. That game still has over 100 items (although not nearly as many as TBOI's now 600+ count) but each item, despite having much less significant effects than many items in TBOI, still feels impactful and helpful.
ROR2 has no items (not counting the Heretic's transformation items) like Brimstone which completely modify your attack into something far more powerful and effective. A vast majority of the items in ROR2 are small stat boosts, passive effects, or additional automatic attacks which all boost your ability to defend yourself. Everything feels like it contributes to a build, and everything feels like it has a purpose. Additionally, the inclusion of Multishops, multiple chest types, and Printers (paired with Scrappers to remove the chance-based item removal of said printers) gives you almost full control over your build, while the randomness of chests still keeps each run's items different enough to justify the game's existence as a roguelite.
Overall, I just really don't like Isaac as a huge fan of the roguelike and roguelite genres. Maybe that's all I needed to say.