I should give KotH, Boondocks, MTM and B&B a chance but I loved watching Daria and Archer (despite many issues I got with post-Archer Vice seasons despite how I liked some such as 1999 but I firmly think that the 5th one would've been the perfect conclusion of the franchise and I'm still mad they left out many sub-plots like Veronica Dean and Conway so we won't ever know their whereabouts). I should rewatch Daria someday, I really liked some of the episodes but it was so long ago I kinda forgot.
I firmly believe that some of the shows making an actual meta-commentary about social aspects (despite how time-relevant they may be) are maybe requiring good writing so most sitcoms prefer to go for the easier audience-catching techniques such as putting violence like a Warner Bros cartoon (but with more blood) but ironically explicit material, even if this is only for the adult audience late in the night (or early in the morning depending on the clock) seems to be strictly forbidden.
PS: Have you watched Harvey Birdman Attorney at Law and Metalocalypse?