The Binding of Isaac and Enter the Gungeon are my favorites by far, and Dead Cells in the second places. But to no say the most popular, I could mention Neurovoider, Dungeon of the Endless, and Crying Suns. All of them highly recommended.
Crying suns is a tactical space-ship battle game, more paused, and with a more interesting history.
Neurovoider plays in the same league that Enter the gungeon or nuclear throne, frenetic shooter, more hardcore, and very colorful.
Dungeon of the Endless is my favorite of those, is a mix of tower defense turn based and in active time. Basically, the gameplay is in active time, but every time you open a door in the duungeon, the time advance one turn.
Crying suns is a tactical space-ship battle game, more paused, and with a more interesting history.
Neurovoider plays in the same league that Enter the gungeon or nuclear throne, frenetic shooter, more hardcore, and very colorful.
Dungeon of the Endless is my favorite of those, is a mix of tower defense turn based and in active time. Basically, the gameplay is in active time, but every time you open a door in the duungeon, the time advance one turn.