I noticed as a kid that scanlines (on genesis and snes emulators) dims the picture slightly, but also the way the brain works it softens edges so curves look more like curves. Course that's literally 2x resolution and every other line is black...
Unless it's an especially low resolution game on a high resolution screen (NES/SNES/Genesis being prime candidates, and any 8bit systems too) then i might avoid it.
On the other hand it does make it a bit easier on the eyes if you're somewhat used to it. If you aren't used to it, probably avoid it.
View attachment 12886