POLICENAUTS by Hideo Kojima
This is one of the most interesting stories about social isolation I've ever experienced.
This is sort of a spoiler, but it's in the first hour of the game so it's not so bad. You play as Jonathan Ingram. He was one of the founding members of the Policenauts, the law enforcement of the first human space colony. After an accident during a space walk causes him to fly away from the colony, Jonathan's suit puts his body into a suspended sentence to save his life. Decades later, they recover Jonathan and wake him up. For him, it was minutes of separation. For the rest of the universe, it was years.
If you've ever talked long enough with a grandparent, you'll be familiar with how they feel like the world is no longer meant for them. They've aged, the place they grew up in is long gone. Somehow they feel like foreigners in their own home. Policenauts has almost the opposite feel to it. Jonathan didn't change, he never got old. It was the world that aged. He went to sleep and woke up still in love with his wife but that's not how she experienced it. She grieved, moved on, met someone else, remarried, had a daughter, got a new job, moved into a colony. All of this happened without Jonathan even being conscious.
This isolation, the feeling like the world isn't what it used to be, is sort of unique to Policenauts. Jonathan is the new, he's young and excited to help people. Yet none of it really matters anymore. Friends have turned into enemies, lovers into clientele, and standards and traditions have been forgotten. Things have gotten a lot more complicated since he went to sleep and the world isn't willing to give him an explanation.
Policenauts has had a dozen ports and plenty of fan translations. I suggest the Sega Saturn version because it included a documentary, the updated art, and slightly higher quality audio. I know it's not Metal Gear, but I seriously think this game is the best of Hideo Kojima's catalogue. At the very least, in his top 5.